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1
Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
Springer-Verlag New York
Dhiren R. Thakker (auth.)
,
Ronald T. Borchardt
,
Edward H. Kerns
,
Michael J. Hageman
,
Dhiren R. Thakker
,
James L. Stevens (eds.)
brain
compounds
transport
solubility
optimization
permeability
vitro
studies
models
figure
discovery
plasma
dose
absorption
binding
drugs
idiosyncratic
reactions
protein
clinical
pgp
uptake
oral
toxicity
metabolism
activity
assay
intestinal
lipid
efflux
liver
clearance
membrane
mice
assays
formulation
pharm
reactive
bbb
delivery
preclinical
prodrug
transporters
glycoprotein
toxicology
chemical
transporter
adme
barrier
metabolic
Anno:
2006
Lingua:
english
File:
PDF, 12.63 MB
I tuoi tag:
0
/
0
english, 2006
2
Optimizing the ''Drug-Like'' Properties of Leads in Drug Discovery
Springer
Ronald T. Borchardt
,
Edward H. Kerns
,
Michael J. Hageman
,
Dhrien R. Thakker
,
James L. Stevens
brain
compounds
transport
solubility
optimization
permeability
vitro
studies
models
figure
discovery
plasma
dose
absorption
binding
drugs
idiosyncratic
reactions
protein
clinical
pgp
uptake
oral
toxicity
metabolism
activity
assay
intestinal
lipid
efflux
liver
clearance
membrane
mice
assays
formulation
pharm
reactive
bbb
delivery
preclinical
prodrug
transporters
glycoprotein
toxicology
chemical
transporter
adme
barrier
metabolic
Anno:
2006
Lingua:
english
File:
PDF, 13.03 MB
I tuoi tag:
0
/
0
english, 2006
3
The BlooddBrain Barrier and Drug Delivery to the CNS
Informa Healthcare
Michael Bradbury
,
David Begley
,
Jorg Kreuter
brain
transport
barrier
dekker
marcel
bbb
reserved
endothelial
drugs
delivery
pgp
uptake
binding
mice
receptor
activity
resistance
mediated
glycoprotein
values
vitro
plasma
effect
capillary
nanoparticles
peptide
membrane
tissue
compounds
equation
fluid
pharmacol
peptides
cns
efflux
administration
studies
specific
mdr1a
permeability
serum
pardridge
transporter
concentrations
effects
proteins
cerebral
microdialysis
protein
active
Anno:
2000
Lingua:
english
File:
PDF, 2.16 MB
I tuoi tag:
0
/
0
english, 2000
4
Nature Biotechnology 01 2011 (magazine journal; January 2011)
Andrew Marshall
genome
dna
gene
supplementary
sequencing
hmc
genomic
biotechnology
analysis
patent
ips
vector
companies
reserved
pharma
technology
genes
haplotype
volume
haplotypes
january
mouse
clones
trials
drugs
products
mice
globin
snps
approach
clinical
methods
shrna
biotech
chromosome
pcr
market
specific
figure
industry
patients
targeting
protein
targeted
allele
homologous
phasing
transgenic
genomes
target
Lingua:
english
File:
PDF, 10.89 MB
I tuoi tag:
0
/
0
english
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